As a typical hazard threat for buried pipelines, an active fault can induce large plastic deformation in a pipe, leading to rupture failure. The mechanical behavior of high-strength X80 pipeline subjected to strike-slip fault displacements was investigated in detail in the presented study with parametric analysis performed by the finite element model, which simulates pipe and soil constraints on pipe by shell and nonlinear spring elements respectively. Accuracy of the numerical model was validated by previous full-scale experimental results. Insight of local buckling response of high-strength pipe under compressive strike-slip fault was revealed. Effects of the pipe-fault intersection angle, pipe operation pressure, pipe wall thickness, soil parameters and pipe buried depth on critical section axial force in buckled area, critical fault displacement, critical compressive strain and post buckling response were elucidated comprehensively. In addition, feasibility of some common buckling failure criteria (i.e., the CSA Z662 model proposed by Canadian Standard association, the UOA model proposed by University of Alberta and the CRES-GB50470 model proposed by Center of Reliable Energy System) was discussed by comparing with numerical results. This study can be referenced for performance-based design and assessment of buried high-strength pipe in geo-hazard areas.