Volume 10 Issue 2
Exploring the Chemical Diversity of Algerian Plants: Three New Pentacyclic Triterpenoids from Launaea acanthoclada Roots
Nabila Zergainoh, Maria Letizia Ciavatta, Marianna Carbone, Fatma Bitam, Mohamed Cherif Aberkane and Margherita Gavagnin
1National Research Council (CNR), Institute of Biomolecular Chemistry (ICB), Via Campi Flegrei, 34, 80078 Pozzuoli (Naples), Italy
2Laboratory of Chemistry and Environmental Chemistry (L.C.C.E), Department of Chemistry, Faculty of Sciences of the Matter, University of Batna 1, 05000 Batna, Algeria
3Department of Pharmacy, University of Batna 2, Faculty of Medicine, 05000 Batna, Algeria
*Author to whom correspondence should be addressed.
Abstract
The chemical study of Launaea acanthoclada from South-East Algeria led to the isolation of twelve oxygenated terpenoid compounds, including three new pentacyclic triterpenoids 1–3 with either lupane or ursane rearranged skeletons. The structure and the stereochemistry of these compounds were established by spectroscopic methods, including NMR techniques. The chemical pattern of L. acanthoclada is in accordance with the triterpenoid scenario of the genus Launaea embracing to date lupane, oleane, ursane and taraxastane skeletons. However, the carbon frameworks exhibited by new compounds 1–3 have never been reported from Launaea species.
Keywords:Launaea acanthoclada; triterpenoids; lupane; bauerane; structural elucidation; NMR